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Article

Sirtuins Are Evolutionarily Conserved Viral Restriction Factors

17 Dec 2014

Abstract excerpt

UNLABELLED: The seven human sirtuins are a family of ubiquitously expressed and evolutionarily conserved NAD(+)-dependent deacylases/mono-ADP ribosyltransferases that regulate numerous cellular and organismal functions, including metabolism, cell cycle, and longevity. Here, we report the discovery that all seven sirtuins have broad-range antiviral properties. We demonstrate that small interfering RNA...

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PMID: 25516616
DOI: 10.1128/mbio.02249-14

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