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Article

G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease

1 Jan 2024

Abstract excerpt

Epigenetic alterations are a fundamental pathological hallmark of Alzheimer's disease (AD). Herein, we show the upregulation of G9a and H3K9me2 in the brains of AD patients. Interestingly, treatment with a G9a inhibitor (G9ai) in SAMP8 mice reversed the high levels of H3K9me2 and rescued cognitive decline. A transcriptional profile analysis after G9ai treatment revealed increased gene expression of glia...

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PMID: 37307824
DOI: 10.14336/ad.2023.0424-2

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