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Article

The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout

1 Jan 2012

Abstract excerpt

Neuroinflammation is one of the important pathogenic features of Alzheimer's disease (AD). Recently, S100a9 was found to be increased within neuritic plaques and reactive glia and was proposed to participate in the inflammation associated with the pathogenesis of AD. Our study showed that S100a9 expression was increased in the brains of AD mice and AD patients. In Tg2576 mice, knockdown by short hairpin RNA or...

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PMID: 22301734
DOI: 10.1159/000333781

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