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Article

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

The Journal of biological chemistry - 26 Sept 2008

Pless Ole, Kowenz-Leutz Elisabeth, Knoblich Maria, Lausen Jörn, Beyermann Michael, Walsh Martin J, Leutz Achim

Abstract excerpt

The functional capacity of the transcriptional regulatory CCAAT/enhancer-binding protein-beta (C/EBPbeta) is governed by protein interactions and post-translational protein modifications. In a proteome-wide interaction screen, the histone-lysine N-methyltransferase, H3 lysine 9-specific 3 (G9a), was found to directly interact with the C/EBPbeta transactivation domain (TAD). Binding between G9a and C/EBPbeta was...

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Identifiers

PMID: 18647749
DOI: 10.1074/jbc.M802132200
PMCID: PMC3258912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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