Article

Uncovering the role of G9a modulatory landscape promoting neuronal plasticity and neuroprotection in Alzheimer's disease

2022-01-05

Abstract excerpt

<title>Abstract</title> <p>Epigenetic alterations are a fundamental pathological hallmark of Alzheimer’s disease (AD). Herein, we uncover the unknown G9a modulation pathways involved in AD, showing the upregulation of G9a and H3K9me2 in the brains of AD patients. Likewise, treatment with a G9a inhibitor in SAMP8 mice reversed the high levels of H3K9me2 and rescued the cognitive decline. Interestingly, a transcrip...

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Literature Corpus work: 94434e38-e304-5f7f-98b3-05aa28685371
DOI: 10.21203/rs.3.rs-1228952/v1

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