Article
Prevalence and Distribution of Unexpected Actionable Germline Pathogenic Variants Identified on Broad-Based Multigene Panel Testing Among Patients With Cancer.
JCO precision oncology - 1 Dec 2024
Landry Kara K, DeSarno Michael J, Kipnis Lindsay, Barquet Ramos Farid, Breen Katelyn M, Patton Kaleigh, Morrissette Audrey, Buehler Ryan M, Ukaegbu Chinedu, Rohanizadegan Mersedeh, Yurgelun Matthew B, Syngal Sapna, Rana Huma Q, Garber Judy E
Abstract excerpt
PURPOSE: In patients with a variety of malignancies undergoing multigene panel testing (MGPT), we examined the frequency of a pathogenic/likely pathogenic variant (PV) that would not have been predicted on the basis of the patient's personal and family history of cancer. METHODS: This is a retrospective review of patients with cancer ascertained from a single academic cancer center who underwent broad-based MGPT...
Topics
- Humans
- Male
- Retrospective Studies
- Female
- Neoplasms
- Middle Aged
- Genetic Testing
- Germ-Line Mutation
- Genetic Predisposition to Disease