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Article

Human disposition, metabolism and excretion of etamicastat, a reversible, peripherally selective dopamine β-hydroxylase inhibitor.

British journal of clinical pharmacology - 1 Jun 2014

Loureiro Ana I, Rocha Jose F, Fernandes-Lopes Carlos, Nunes Teresa, Wright Lyndon C, Almeida Luis, Soares-da-Silva Patricio

Abstract excerpt

AIMS: Etamicastat is a reversible dopamine-β-hydroxylase inhibitor that decreases noradrenaline levels in sympathetically innervated tissues and slows down sympathetic nervous system drive. In this study, the disposition, metabolism and excretion of etamicastat were evaluated following [(14)C]-etamicastat dosing. METHODS: Healthy Caucasian males (n = 4) were enrolled in this single-dose, open-label study....

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Identifiers

PMID: 24168152
DOI: 10.1111/bcp.12274
PMCID: PMC4093927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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