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Article

Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01.

Scientific reports - 9 Jun 2023

Huan Xuelu, Zhuo Nicole, Lee Haur Yueh, Ren Ee Chee

Abstract excerpt

Allopurinol, widely used in gout treatment, is the most common cause of severe cutaneous adverse drug reactions. The risk of developing such life-threatening reactions is increased particularly for HLA-B*58:01 positive individuals. However the mechanism of action between allopurinol and HLA remains unknown. We demonstrate here that a Lamin A/C peptide KAGQVVTI which is unable to bind HLA-B*58:01 on its own, is...

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Identifiers

PMID: 37296297
DOI: 10.1038/s41598-023-36293-z
PMCID: PMC10256732

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