Article
Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2013
Yun J, Mattsson J, Schnyder K, Fontana S, Largiadèr C R, Pichler W J, Yerly D
Abstract excerpt
BACKGROUND: Allopurinol is a main cause of severe cutaneous adverse reactions (SCAR). How allopurinol induces hypersensitivity remains unknown. Pre-disposing factors are the presence of the HLA-B*58:01 allele, renal failure and possibly the dose taken. OBJECTIVE: Using an in vitro model, we sought to decipher the relationship among allopurinol metabolism, HLA-B*58:01 phenotype and drug concentrations in...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aldehyde Oxidase
- Alleles
- Allopurinol
- Cross Reactions
- Dose-Response Relationship, Drug
- Drug Hypersensitivity
- Gout Suppressants
- HLA-B Antigens
- Humans
- Lymphocyte Activation
- Middle Aged