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Article

Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2013

Yun J, Mattsson J, Schnyder K, Fontana S, Largiadèr C R, Pichler W J, Yerly D

Abstract excerpt

BACKGROUND: Allopurinol is a main cause of severe cutaneous adverse reactions (SCAR). How allopurinol induces hypersensitivity remains unknown. Pre-disposing factors are the presence of the HLA-B*58:01 allele, renal failure and possibly the dose taken. OBJECTIVE: Using an in vitro model, we sought to decipher the relationship among allopurinol metabolism, HLA-B*58:01 phenotype and drug concentrations in...

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Identifiers

PMID: 24152157
DOI: 10.1111/cea.12184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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