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Article

P-Cadherin Promotes Cell-Cell Adhesion and Counteracts Invasion in Human Melanoma

1 Oct 2005

Abstract excerpt

Malignant transformation of melanocytes frequently coincides with alterations in epithelial cadherin (E-cadherin) expression, switching on of neural cadherin (N-cadherin), and, when progressed to a metastatic stage, loss of membranous placental cadherin (P-cadherin). In vitro studies of melanoma cell lines have shown invasion suppressor and promoter roles for E-cadherin and N-cadherin, respectively. In the...

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PMID: 16204047
DOI: 10.1158/0008-5472.can-04-4414

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