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Article

Loss of cell invasiveness through PKC-mediated syndecan-1 downregulation in melanoma cells under anchorage independency.

Experimental dermatology - 1 Nov 2014

Wang ChiaChen, Tseng TingTing, Jhang Yaoyun, Tseng JenChih, Hsieh ChiaoHui, Wu Wen-guey, Lee ShaoChen

Abstract excerpt

Anchorage-independent survival is one of the key features for malignant tumor cells. Whether specific gene alterations contributed by anchorage independency would further affect metastatic phenotypes of melanoma cells was unclear. We adapted suspension culture of melanoma cells to establish anchorage independency. The suspended melanoma cells lost their invasive abilities in vitro. Specific loss of...

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PMID: 25236603
DOI: 10.1111/exd.12550

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SDC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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