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Article

Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact.

Scientific reports - 16 Mar 2017

Zhang Lifang, Okada Taro, Badawy Shaymaa Mohamed Mohadmed, Hirai Chihoko, Kajimoto Taketoshi, Nakamura Shun-Ichi

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disorder. The presence of α-synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies, is the cytopathological hallmark of PD. Increasing bodies of evidence suggest that cell-to-cell transmission of α-Syn plays a role in the progression of PD. Although extracellular α-Syn is known to cause abnormal cell motility, the precise...

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Identifiers

PMID: 28300069
DOI: 10.1038/srep44248
PMCID: PMC5353548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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