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Article

Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system.

Neurobiology of disease - 1 Jul 2023

Fominykh Vera, Shadrin Alexey A, Jaholkowski Piotr P, Bahrami Shahram, Athanasiu Lavinia, Wightman Douglas P, Uffelmann Emil, Posthuma Danielle, Selbæk Geir, Dale Anders M, Djurovic Srdjan, Frei Oleksandr, Andreassen Ole A

Abstract excerpt

BACKGROUND: Neuroinflammation is involved in the pathophysiology of Alzheimer's disease (AD), including immune-linked genetic variants and molecular pathways, microglia and astrocytes. Multiple Sclerosis (MS) is a chronic, immune-mediated disease with genetic and environmental risk factors and neuropathological features. There are clinical and pathobiological similarities between AD and MS. Here, we investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37286172
DOI: 10.1016/j.nbd.2023.106174

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