Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.

doi:10.1001/jamaneurol.2016.0150

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Article

Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.

JAMA neurology - 1 Jun 2016

Yokoyama Jennifer S, Wang Yunpeng, Schork Andrew J, Thompson Wesley K, Karch Celeste M, Cruchaga Carlos, McEvoy Linda K, Witoelar Aree, Chen Chi-Hua, Holland Dominic, Brewer James B, Franke Andre, Dillon William P, Wilson David M, Mukherjee Pratik, Hess Christopher P, Miller Zachary, Bonham Luke W, Shen Jeffrey, Rabinovici Gil D, Rosen Howard J, Miller Bruce L, Hyman Bradley T, Schellenberg Gerard D, Karlsen Tom H, Andreassen Ole A, Dale Anders M, Desikan Rahul S

Abstract excerpt

IMPORTANCE: Late-onset Alzheimer disease (AD), the most common form of dementia, places a large burden on families and society. Although epidemiological and clinical evidence suggests a relationship between inflammation and AD, their relationship is not well understood and could have implications for treatment and prevention strategies. OBJECTIVE: To determine whether a subset of genes involved with increased...

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PMID: 27088644
DOI: 10.1001/jamaneurol.2016.0150
PMCID: PMC4905783

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