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Expression, purification, and microscopic characterization of the tumor suppressor KLHL6.

Protein expression and purification - 1 Oct 2023

Han Lin, Chen Zhenguo, Sun Lei

Abstract excerpt

Kelch-like protein 6 (KLHL6) plays a critical role in preventing the development and survival of diffuse large B-cell lymphoma (DLBCL) through its involvement in the ubiquitin proteasome system. Specifically, KLHL6 binds to cullin3 (Cul3) and the substrate, facilitating the assembly of the E3 ligase responsible for substrate ubiquitination. It is imperative to investigate the precise function of KLHL6 by...

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PMID: 37286065
DOI: 10.1016/j.pep.2023.106318

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