Article
Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.
Structure (London, England : 1993) - 4 Aug 2015
Quaile Andrew T, Urbanus Malene L, Stogios Peter J, Nocek Boguslaw, Skarina Tatiana, Ensminger Alexander W, Savchenko Alexei
Abstract excerpt
LubX is part of the large arsenal of effectors in Legionella pneumophila that are translocated into the host cytosol during infection. Despite such unique features as the presence of two U-box motifs and its targeting of another effector SidH, the molecular basis of LubX activity remains poorly understood. Here we show that the N terminus of LubX is able to activate an extended number of ubiquitin-conjugating...
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