Article
Lectin-Type Ubiquitin Ligase Subunits: Fbs Proteins and Their Applications for Use.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Yoshida Yukiko
Abstract excerpt
Three lectin-type F-box proteins called Fbs (F-box protein-recognizing sugar chains) are found in mammals, and function as substrate-binding subunits in the SCF (Skp1/Cullin1/F-box protein) complex ubiquitin ligases. The SCFFbs recognizes cytosolic N-glycans as a signal for an adverse cellular state, and ubiquitinates glycoproteins which appear in the cytosol to remove them from cells. Although Fbs proteins...
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