Article

KLHL9 acts as a KSHV vBcl-2-interacting host factor that supports lytic replication

2026-08-13

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) is an oncogenic gammaherpesvirus that causes Kaposi's sarcoma and several lymphoproliferative disorders. The KSHV open reading frame (ORF) 16 encodes viral Bcl-2 (vBcl-2), which inhibits apoptosis and autophagy. vBcl-2 is required for efficient lytic replication and production of infectious progeny; however, this essential role is independent of i...

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Literature Corpus work: bef8e5bd-5f97-5961-ab0a-536c3277327e
DOI: 10.64898/2026.08.13.744635

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