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Article

Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-Cell Lymphoma.

Blood cancer discovery - 3 Sept 2024

Meriranta Leo, Sorri Selma, Huse Kanutte, Liu Xiaonan, Spasevska Ivana, Zafar Sadia, Chowdhury Iftekhar, Dufva Olli, Sahlberg Eerika, Tandarić Luka, Karjalainen-Lindsberg Marja-Liisa, Hyytiäinen Marko, Varjosalo Markku, Myklebust June H, Leppä Sirpa

Abstract excerpt

Pathomechanisms that activate oncogenic B-cell receptor (BCR) signaling in diffuse large B-cell lymphoma (DLBCL) are largely unknown. Kelch-like family member 6 (KLHL6) encoding a substrate-adapter for Cullin-3-RING E3 ubiquitin ligase with poorly established targets is recurrently mutated in DLBCL. By applying high-throughput protein interactome screens and functional characterization, we discovered that KLHL6...

Topics

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Adaptor Proteins, Signal Transducing
Carrier Proteins
CD79 Antigens
Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Large B-Cell, Diffuse

Microfilament Proteins

Receptors, Antigen, B-Cell

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 38630892
DOI: 10.1158/2643-3230.BCD-23-0182
PMCID: PMC11369598

Genes

KLHL6
BCR
CD79B
CD79A
C5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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