Article
Efficient network-guided multi-locus association mapping with graph cuts.
Bioinformatics (Oxford, England) - 1 Jul 2013
Azencott Chloé-Agathe, Grimm Dominik, Sugiyama Mahito, Kawahara Yoshinobu, Borgwardt Karsten M
Abstract excerpt
MOTIVATION: As an increasing number of genome-wide association studies reveal the limitations of the attempt to explain phenotypic heritability by single genetic loci, there is a recent focus on associating complex phenotypes with sets of genetic loci. Although several methods for multi-locus mapping have been proposed, it is often unclear how to relate the detected loci to the growing knowledge about gene...
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