Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome amplification and cellular senescence are hallmarks of human placenta development

12 Oct 2018

Abstract excerpt

Genome amplification and cellular senescence are commonly associated with pathological processes. While physiological roles for polyploidization and senescence have been described in mouse development, controversy exists over their significance in humans. Here, we describe tetraploidization and senescence as phenomena of normal human placenta development. During pregnancy, placental extravillous trophoblasts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Gestational Trophoblastic Disease Studies
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30312291
DOI: 10.1371/journal.pgen.1007698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome amplification and cellular senescence are hallmarks of human placenta developmentPMID 30312291Read ↗

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous TrophoblastSemantic proximity Read ↗

Myc promotes polyploidy in murine trophoblast cells and suppresses senescenceSemantic proximity Read ↗

Role of cell cycling and polyploidy in placental trophoblast of different mammalian speciesSemantic proximity Read ↗

Chromosomal instability in human trophoblast stem cells and placentasSemantic proximity Read ↗

Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cellsSemantic proximity Read ↗

Trophoblast 'pseudo-tumorigenesis': Significance and contributory factorsSemantic proximity Read ↗

Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndromeSemantic proximity Read ↗

Towards prevention of aneuploidy-associated cellular senescence and aging: more questions than answers?Semantic proximity Read ↗

Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype.Semantic proximity Read ↗

Cell dynamics in human villous trophoblastSemantic proximity Read ↗

Developmental regulation of decidual cell polyploidy at the site of implantationSemantic proximity Read ↗

Molecular Pathways of Cellular Senescence and Placental Aging in Late Fetal Growth Restriction and StillbirthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.