Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast

3 Sept 2021

Abstract excerpt

During pregnancy, conceptus-derived extravillous trophoblast (EVT) invades the endomyometrium, anchors the placenta to the maternal uterus, and remodels the spiral arteries in order to establish maternal blood supply to the fetoplacental unit. Recent reports have described early gestation EVT as polyploid and senescent. Here, we extend these reports by performing comprehensive profiling of both the genomic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neonatal Respiratory Health Research
Share to Pregnancy and preeclampsia studies
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34540826
DOI: 10.3389/fcell.2021.702046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous TrophoblastPMID 34540826Read ↗

Genome amplification and cellular senescence are hallmarks of human placenta developmentSemantic proximity Read ↗

Myc promotes polyploidy in murine trophoblast cells and suppresses senescenceSemantic proximity Read ↗

Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cellsSemantic proximity Read ↗

Establishment of the fetal-maternal interface: developmental events in human implantation and placentationSemantic proximity Read ↗

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA SequencingSemantic proximity Read ↗

A Multiomics, Spatiotemporal, and Single Cell Atlas for Mapping Cell-Type-Specific Dysregulation at the Maternal-Fetal InterfaceSemantic proximity Read ↗

Trophoblast Cell Subtypes and Dysfunction in the Placenta of Individuals with Preeclampsia Revealed by Single-Cell RNA SequencingSemantic proximity Read ↗

Single-Cell Atlas of Patient-Derived Trophoblast Organoids in Ongoing PregnanciesSemantic proximity Read ↗

An integrated atlas of human placental development delineates essential regulators of trophoblast stem cellsSemantic proximity Read ↗

Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal–fetal interfaceSemantic proximity Read ↗

Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal-fetal interfaceSemantic proximity Read ↗

Single-cell RNA-seq reveals developmental deficiencies in both the placentation and the decidualization in women with late-onset preeclampsiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.