The Expanding Role of Alternative Splicing in Vascular Smooth Muscle Cell Plasticity.

Abstract excerpt

Vascular smooth muscle cells (VSMCs) display extraordinary phenotypic plasticity. This allows them to differentiate or dedifferentiate, depending on environmental cues. The ability to 'switch' between a quiescent contractile phenotype to a highly proliferative synthetic state renders VSMCs as primary mediators of vascular repair and remodelling. When their plasticity is pathological, it can lead to cardiovascular...

Topics

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• Alternative Splicing
• Atherosclerosis
• Cell Plasticity
• Coronary Restenosis
• Muscle, Smooth, Vascular