Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA‑199a‑5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch.

Molecular medicine reports - 1 Sept 2021

Cao Yushi, Cao Zhongwen, Wang Weitie, Jie Xiangyu, Li Lei

Abstract excerpt

Varicose veins are among the most common disorders of the vascular system; however, the pathogenesis of varicose veins remains unclear. The present study aimed to investigate the roles of microRNA (miR)‑199a‑5p in varicose veins and in the phenotypic transition of vascular smooth muscle cells (VSMCs). Bioinformatics analysis confirmed that miR‑199a‑5p had target sites on the forkhead box C2 (FOXC2)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Calponins
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microfilament Proteins

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Saphenous Vein

Share to Varicose Veins

Source

Open in PubMed Open full text

Identifiers

PMID: 34212977
DOI: 10.3892/mmr.2021.12266
PMCID: PMC8281299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA‑199a‑5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch.PMID 34212977Read ↗

FOXC2-AS1 regulates phenotypic transition, proliferation and migration of human great saphenous vein smooth muscle cells.Semantic proximity Read ↗

Phenotypic Transition of Vascular Smooth Muscle Cells Induced by Endothelial TIE2 Mutations in Venous MalformationsSemantic proximity Read ↗

miR-342-5p promotes vascular smooth muscle cell phenotypic transition through a negative-feedback regulation of Notch signaling via targeting FOXO3.Semantic proximity Read ↗

Hypoxia-induced miR-182-5p regulates vascular smooth muscle cell phenotypic switch by targeting RGS5.Semantic proximity Read ↗

Elevated c-fos expression is correlated with phenotypic switching of human vascular smooth muscle cells derived from lower limb venous varicosities.Semantic proximity Read ↗

IQGAP1 promotes the phenotypic switch of vascular smooth muscle by myocardin pathway: a potential target for varicose vein.Semantic proximity Read ↗

MicroRNA regulation of phenotypic transformations in vascular smooth muscle: relevance to vascular remodeling.Semantic proximity Read ↗

How do microRNAs affect vascular smooth muscle cell biology?Semantic proximity Read ↗

miR-125a-5p Modulates Phenotypic Switch of Vascular Smooth Muscle Cells by Targeting ETS-1Semantic proximity Read ↗

MicroRNA regulation of smooth muscle gene expression and phenotype.Semantic proximity Read ↗

Phenotypic and functional transformation in smooth muscle cells derived from varicose veins.Semantic proximity Read ↗

Functional screening identifies novel miRNAs inhibiting Vascular Smooth Muscle Cell proliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.