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Article

SM22α+ vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling.

Journal of experimental & clinical cancer research : CR - 2 Jul 2020

Zhang Xinxin, Yan Xianchun, Cao Jing, Yang Ziyan, Cao Xiuli, Zhang Yufei, Liang Liang, Zheng Minhua, Liu Xiaowei, Zhang Jian, Han Hua

Abstract excerpt

BACKGROUND: Malformation of blood vessels represents a hallmark of cancers, but the role and regulation of vascular mural cells (vMCs), including vascular smooth muscle cells (vSMCs) and pericytes, in tumors has not been fully understood. SM22α has been identified as a marker of vSMCs. This study aims at elucidating the function and regulation of SM22α+ mural cells (SM22-MCs) in tumor stroma. METHODS:...

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Identifiers

PMID: 32616053
DOI: 10.1186/s13046-020-01630-x
PMCID: PMC7331127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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