Article
Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy.
Scientific reports - 18 Oct 2016
Fujii Chihiro, Kondo Takayuki, Ochi Hirofumi, Okada Yoichiro, Hashi Yuichiro, Adachi Tetsuya, Shin-Ya Masaharu, Matsumoto Sadayuki, Takahashi Ryosuke, Nakagawa Masanori, Mizuno Toshiki
Abstract excerpt
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease. Fingolimod, a highly effective disease-modifying drug for MS, retains CCR7+ central memory T cells in which autoaggressive T cells putatively exist, in secondary lymphoid organs, although relapse may still occur in some patients. Here, we analyzed the T cell phenotypes of fingolimod-treated, fingolimod-untreated patients, and healthy subjects. The...
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