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Article

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

1 Jun 2023

Abstract excerpt

Despite the remarkable success of immune checkpoint blockade (ICB) therapy, most cancer patients still do not respond. We now find that immunotherapy can induce stem-like properties in tumors. Using mouse models of breast cancer, we observe that cancer stem cells (CSCs) show not only enhanced resistance to T cell cytotoxicity, but that interferon gamma (IFNγ) produced by activated T cells directly converts...

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PMID: 37267916
DOI: 10.1016/j.stem.2023.05.007

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