Article

Breast cancer stem cells mediated CD8 <sup>+</sup> T cell exhaustion among different molecular subtypes of breast cancer regulated via NOTCH1/RBPJ/PD-L1 axis

2026-05-26

Abstract excerpt

<h4>Background</h4> Breast cancer stem cells (BCSCs) contribute significantly to breast cancer (BC) mortality among women globally. It underpins tumor heterogeneity in BC by driving variations in stemness potential and altering immune microenvironment. However, how BCSCs, subpopulations of breast cancer cells from distinct molecular subtypes differentially modulate CD8⁺ T-cell exhaustion and immune dysfunction re...

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Literature Corpus work: ec94a910-0ed8-5e8a-b07f-d0416b24bfc9
DOI: 10.64898/2026.05.22.727059

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