Article
Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.
Immunology and cell biology - 1 Aug 2017
Chen Hung-Chang, Joalland Noémie, Bridgeman John S, Alchami Fouad S, Jarry Ulrich, Khan Mohd Wajid A, Piggott Luke, Shanneik Yasmin, Li Jianqiang, Herold Marco J, Herrmann Thomas, Price David A, Gallimore Awen M, Clarkson Richard W, Scotet Emmanuel, Moser Bernhard, Eberl Matthias
Abstract excerpt
The inherent resistance of cancer stem cells (CSCs) to existing therapies has largely hampered the development of effective treatments for advanced malignancy. To help develop novel immunotherapy approaches that efficiently target CSCs, an experimental model allowing reliable distinction of CSCs and non-CSCs was set up to study their interaction with non-MHC-restricted γδ T cells and antigen-specific CD8+ T...
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