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Article

Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images.

Science (New York, N.Y.) - 2 Jun 2023

Zhao Bingxin, Li Tengfei, Fan Zirui, Yang Yue, Shu Juan, Yang Xiaochen, Wang Xifeng, Luo Tianyou, Tang Jiarui, Xiong Di, Wu Zhenyi, Li Bingxuan, Chen Jie, Shan Yue, Tomlinson Chalmer, Zhu Ziliang, Li Yun, Stein Jason L, Zhu Hongtu

Abstract excerpt

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns with brain gray matter morphometry, white matter microstructure, and...

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PMID: 37262162
DOI: 10.1126/science.abn6598

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