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Brain Aging Mediating Heart Imaging-Derived Phenotypes and Mental and Nervous System Disorders.

Aging cell - 1 May 2026

Zhou Zairen, Su Wenjing, Li Yuna, Zhang Bei, Lan Fang, Lin Dawei, Yu Jin-Tai, Feng Jianfeng, Jin Yifei, Ren Peng, Cheng Wei

Abstract excerpt

Mental and nervous system disorders often co-occur with cardiovascular diseases in aging populations, yet the biological relationships underlying these associations remain incompletely understood. Using heart and brain imaging data from 33,573 UK Biobank (UKB) participants, we developed a brain age prediction model to estimate the brain age gap (BAG), an imaging-based marker of brain aging. We then examined BAG...

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Identifiers

PMID: 42021636
DOI: 10.1111/acel.70499
PMCID: PMC13103654

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