The brain-heart axis: Integrative analysis of the shared genetic etiology between neuropsychiatric disorders and cardiovascular disease.

doi:10.1016/j.jad.2024.03.098

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Article

The brain-heart axis: Integrative analysis of the shared genetic etiology between neuropsychiatric disorders and cardiovascular disease.

Journal of affective disorders - 15 Jun 2024

Chen Feifan, Dong Xinyu, Yu Zhiwei, Zhang Yihan, Shi Yuan

Abstract excerpt

BACKGROUND: Multiple observational studies have reported substantial comorbidity between neuropsychiatric disorders and cardiovascular disease (CVD), but the underlying mechanisms remain largely unknown. METHODS: Using GWAS summary datasets of 8 neuropsychiatric disorders and 6 cardiovascular diseases, an integrative analysis incorporating linkage-disequilibrium-score-regression (LDSC), Mendelian randomization...

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PMID: 38518856
DOI: 10.1016/j.jad.2024.03.098

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