Article
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.
Nature communications - 7 May 2020
Pirruccello James P, Bick Alexander, Wang Minxian, Chaffin Mark, Friedman Samuel, Yao Jie, Guo Xiuqing, Venkatesh Bharath Ambale, Taylor Kent D, Post Wendy S, Rich Stephen, Lima Joao A C, Rotter Jerome I, Philippakis Anthony, Lubitz Steven A, Ellinor Patrick T, Khera Amit V, Kathiresan Sekar, Aragam Krishna G
Abstract excerpt
Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been associated with DCM, but common variant studies of the disease have yielded few associated loci. As structural changes in the heart are a defining feature of DCM, we report a genome-wide association study of cardiac magnetic resonance imaging (MRI)-derived...
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