Article

A Structural Heart-Brain Axis Mediates the Association Between Cardiovascular Risk and Cognitive Function

2022-09-17

Abstract excerpt

Elevated vascular disease risk associates with poorer cognitive function, but the mechanism for this link is poorly understood. A leading theory, the structural-functional model argues that vascular risk may drive adverse cardiac remodelling, which in turn leads to chronic cerebral hypoperfusion and subsequent brain structural damage. This model predicts that variation in heart and brain structure should associate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16c3a32c-d2ea-54cb-ae01-db00f8cdf520
DOI: 10.1101/2022.09.15.22279275

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Structural Heart-Brain Axis Mediates the Association Between Cardiovascular Risk and Cognitive FunctionDOI 10.1101/2022.09.15.22279275Read

A population-based phenome-wide association study of cardiac and aortic structure and function.Semantic proximity Read

Heart-brain connections: phenotypic and genetic insights from 40,000 cardiac and brain magnetic resonance imagesSemantic proximity Read

Associations of cognitive performance with cardiovascular magnetic resonance phenotypes in the UK Biobank.Semantic proximity Read

Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images.Semantic proximity Read

Association between Echocardiographic Parameters of Cardiac Structure and Function and Mild Cognitive ImpairmentSemantic proximity Read

Association of Right Heart Structure and Function with Cognition and Brain MRI Measures in the Multi-Ethnic Study of AtherosclerosisSemantic proximity Read

Associations of “Life’s Essential 8” cardiovascular health with dementia risk, cognition, and neuroimaging markers of brain healthSemantic proximity Read

Cardiovascular risk and hippocampal-cognitive coupling in Alzheimer’s diseaseSemantic proximity Read

Brain Aging Mediating Heart Imaging-Derived Phenotypes and Mental and Nervous System Disorders.Semantic proximity Read

Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study.Semantic proximity Read

Genetic Interplay Between White Matter Hyperintensities and Alzheimer’s Disease: A Brain-Body PerspectiveSemantic proximity Read

Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure.Semantic proximity Read