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Article

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.

The Journal of clinical investigation - 1 Mar 2016

Landa Iñigo, Ibrahimpasic Tihana, Boucai Laura, Sinha Rileen, Knauf Jeffrey A, Shah Ronak H, Dogan Snjezana, Ricarte-Filho Julio C, Krishnamoorthy Gnana P, Xu Bin, Schultz Nikolaus, Berger Michael F, Sander Chris, Taylor Barry S, Ghossein Ronald, Ganly Ian, Fagin James A

Abstract excerpt

BACKGROUND: Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) are rare and frequently lethal tumors that so far have not been subjected to comprehensive genetic characterization. METHODS: We performed next-generation sequencing of 341 cancer genes from 117 patient-derived PDTCs and ATCs and analyzed the transcriptome of a representative subset of 37 tumors. Results were analyzed in...

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Identifiers

PMID: 26878173
DOI: 10.1172/JCI85271
PMCID: PMC4767360

Genes

BRAF
TERT

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