Characterization of Advanced RAS-driven Follicular-derived Thyroid Cancers and Review of Future Therapeutic Avenues.

doi:10.1210/clinem/dgaf366

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Article

Characterization of Advanced RAS-driven Follicular-derived Thyroid Cancers and Review of Future Therapeutic Avenues.

The Journal of clinical endocrinology and metabolism - 21 Jan 2026

Hamidi Sarah, Maniakas Anastasios, Akhave Neal S, Banuchi Victoria E, Busaidy Naifa L, Dadu Ramona, Ferrarotto Renata, Guise Theresa A, Hofmann Marie-Claude, Hosseini S Mohsen, Hu Mimi I, Iyer Priyanka C, Mansour Mena, Marczyk Vicente R, Roy-Chowdhuri Sinchita, Sherman Steven I, Sousa Luana G, Wang Jennifer R, Williams Michelle D, Zafereo Mark E, Waguespack Steven G, Cabanillas Maria E

Abstract excerpt

CONTEXT: With novel RAS-targeted therapies emerging, better understanding of RAS-driven differentiated (DTC) and anaplastic (ATC) thyroid cancers is warranted. OBJECTIVE: Characterize the genotypic and phenotypic landscape of RAS-driven DTC and ATC and review current and future therapeutic avenues. DESIGN: Retrospective chart review between January 2015 and June 2023. Median follow-up duration 8.4 years in DTC...

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Identifiers

PMID: 40568752
DOI: 10.1210/clinem/dgaf366

Genes

NRAS

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