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Article

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2018

Pozdeyev Nikita, Gay Laurie M, Sokol Ethan S, Hartmaier Ryan, Deaver Kelsi E, Davis Stephanie, French Jena D, Borre Pierre Vanden, LaBarbera Daniel V, Tan Aik-Choon, Schweppe Rebecca E, Fishbein Lauren, Ross Jeffrey S, Haugen Bryan R, Bowles Daniel W

Abstract excerpt

Purpose: To define the genetic landscape of advanced differentiated and anaplastic thyroid cancer (ATC) and identify genetic alterations of potential diagnostic, prognostic, and therapeutic significance.Experimental Design: The genetic profiles of 583 advanced differentiated and 196 ATCs generated with targeted next-generation sequencing cancer-associated gene panels MSK-IMPACT and FoundationOne were...

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Identifiers

PMID: 29615459
DOI: 10.1158/1078-0432.CCR-18-0373
PMCID: PMC6030480

Genes

KDR
KIT
PDGFRA
CCNE1
IMPACT
JAK2
RAC1

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