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Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections

24 Jun 2019

Abstract excerpt

BACKGROUND: T cells play a key role in controlling viral infections; however, the underlying mechanisms regulating their functions during human viral infections remain incompletely understood. Here, we used CD4 T cells derived from individuals with chronic viral infections or healthy T cells treated with camptothecin (CPT) - a topoisomerase I (Top 1) inhibitor - as a model to investigate the role of DNA topology...

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PMID: 31285747
DOI: 10.1186/s12979-019-0153-z

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