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Papillomavirus E1 Protein Binds to and Stimulates Human Topoisomerase I

13 Jan 2006

Abstract excerpt

The papillomavirus (PV) E1 helicase plays a direct role in recruiting cellular DNA replication factors, such as replication protein A or polymerase alpha-primase, to replicate PV genomes. Here, E1 is shown to bind to human topoisomerase I and stimulate its relaxation activity up to sevenfold. The interaction between E1 and topoisomerase I was mapped to the E1 DNA binding domain and C terminus. These findings...

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PMID: 16415033
DOI: 10.1128/jvi.80.3.1584-1587.2006

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