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Article

Succinct workflows for circulating tumor cells after enrichment: From systematic counting to mutational profiling.

PloS one - 1 Jan 2017

Wong Victor Chun-Lam, Ko Josephine Mun-Yee, Lam Chi-Tat, Lung Maria Li

Abstract excerpt

PURPOSE: This study aims to establish a highly adaptable workflow downstream of microfluidic enrichment for facilitating systematic CTC enumeration and genetic discovery. METHODS: To facilitate CTC enumeration, we established a CK/EPCAM-combined immunostaining strategy and an automated CTC analytical pipeline using an open-source image analyzer. By virtue of this workflow, we conducted a pilot study of 56 cancer...

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Identifiers

PMID: 28481895
DOI: 10.1371/journal.pone.0177276
PMCID: PMC5421802

Genes

EPCAM
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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