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Monitoring of cancer patients via next‐generation sequencing of patient‐derived circulating tumor cells and tumor DNA

6 Jun 2019

Abstract excerpt

Liquid biopsy of circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) is gaining attention as a method for real-time monitoring in cancer patients. Conventional methods based upon epithelial cell adhesion molecule (EpCAM) expression have a risk of missing the most aggressive CTC subpopulations due to epithelial-mesenchymal transition and may, thus, underestimate the total number of actual CTC present...

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PMID: 31169336
DOI: 10.1111/cas.14092

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