Article
Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells.
PloS one - 1 Jan 2014
Khoo Bee Luan, Warkiani Majid Ebrahimi, Tan Daniel Shao-Weng, Bhagat Ali Asgar S, Irwin Darryl, Lau Dawn Pingxi, Lim Alvin S T, Lim Kiat Hon, Krisna Sai Sakktee, Lim Wan-Teck, Yap Yoon Sim, Lee Soo Chin, Soo Ross A, Han Jongyoon, Lim Chwee Teck
Abstract excerpt
BACKGROUND: Circulating tumor cells (CTCs) are cancer cells that can be isolated via liquid biopsy from blood and can be phenotypically and genetically characterized to provide critical information for guiding cancer treatment. Current analysis of CTCs is hindered by the throughput, selectivity and specificity of devices or assays used in CTC detection and isolation. METHODOLOGY/PRINCIPAL FINDINGS: Here, we...
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