Inherited variation in immune genes and pathways and glioblastoma risk.

doi:10.1093/carcin/bgq152

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Inherited variation in immune genes and pathways and glioblastoma risk.

Carcinogenesis - 1 Oct 2010

Schwartzbaum Judith A, Xiao Yuanyuan, Liu Yanhong, Tsavachidis Spyros, Berger Mitchel S, Bondy Melissa L, Chang Jeffrey S, Chang Susan M, Decker Paul A, Ding Bo, Hepworth Sarah J, Houlston Richard S, Hosking Fay J, Jenkins Robert B, Kosel Matthew L, McCoy Lucie S, McKinney Patricia A, Muir Kenneth, Patoka Joe S, Prados Michael, Rice Terri, Robertson Lindsay B, Schoemaker Minouk J, Shete Sanjay, Swerdlow Anthony J, Wiemels Joe L, Wiencke John K, Yang Ping, Wrensch Margaret R

Abstract excerpt

To determine whether inherited variations in immune function single-nucleotide polymorphisms (SNPs), genes or pathways affect glioblastoma risk, we analyzed data from recent genome-wide association studies in conjunction with predefined immune function genes and pathways. Gene and pathway analyses were conducted on two independent data sets using 6629 SNPs in 911 genes on 17 immune pathways from 525 glioblastoma...

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PMID: 20668009
DOI: 10.1093/carcin/bgq152
PMCID: PMC2950934

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EGFR

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