Article

Iron-deficiency in the tumor microenvironment reprograms tumor-immune interactions in a sex biased manner

2026-06-02

Abstract excerpt

<h4>Background</h4> Glioblastoma (GBM) is a sex-biased disease characterized by higher incidence and poorer survival in males. These sex differences are primarily driven by metabolic and immune signatures, with iron metabolism playing a major role. While iron is essential for tumor cell proliferation, it is also critical for T cell recruitment and function within the tumor microenvironment (TME). Clinical data in...

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Literature Corpus work: 2a71ca4c-2a74-5534-8907-e4b266aeb37d
DOI: 10.64898/2026.05.29.728615

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