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Article

Clinical Characterization of Targetable Mutations (BRAF V600E and KRAS G12C) in Advanced Colorectal Cancer-A Nation-Wide Study.

International journal of molecular sciences - 22 May 2023

Potocki Paweł M, Wójcik Piotr, Chmura Łukasz, Goc Bartłomiej, Fedewicz Marcin, Bielańska Zofia, Swadźba Jakub, Konopka Kamil, Kwinta Łukasz, Wysocki Piotr J

Abstract excerpt

BRAF V600E and KRAS mutations that occur in colorectal cancer (CRC) define a subpopulation of patients with an inferior prognosis. Recently, the first BRAF V600E-targeting therapy has been approved and novel agents targeting KRAS G12C are being evaluated in CRC. A better understanding of the clinical characteristics of the populations defined by those mutations is needed. We created a retrospective database that...

Topics

Humans
Female
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)
Retrospective Studies
Colorectal Neoplasms
Mutation
Brain Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37240418
DOI: 10.3390/ijms24109073
PMCID: PMC10219350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-37240418-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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