Article
Hydroxychloroquine Attenuates hERG Channel by Promoting the Membrane Channel Degradation: Computational Simulation and Experimental Evidence for QT-Interval Prolongation with Hydroxychloroquine Treatment.
Cardiology - 1 Jan 2023
Wang Xiqiang, Feng Yunfei, Liu Senmiao, Liu Jing, Pan Shuo, Wei Linyan, Ma Yanpeng, Liu Zhongwei, Xing Yujie, Wang Junkui, Cui Qianwei, Zhang Yong, Wang Tingzhong, Cai Chuipu
Abstract excerpt
INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic has led to millions of confirmed cases and deaths worldwide and has no approved therapy. Currently, more than 700 drugs are tested in the COVID-19 clinical trials, and full evaluation of their cardiotoxicity risks is in high demand. METHODS: We mainly focused on hydroxychloroquine (HCQ), one of the most concerned drugs for COVID-19 therapy, and...
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