Article

Use of hiPSC-derived cardiomyocytes to rule out proarrhythmic effects of drugs: the case of hydroxychloroquine in COVID-19

2021-06-25

Abstract excerpt

In the early phases of the COVID-19 pandemic, drug repurposing was widely used to identify compounds that could improve the prognosis of symptomatic patients infected by SARS-CoV-2. Hydroxychloroquine (HCQ) was one of the first drugs used to treat COVID-19 patients due to its supposed capacity of inhibiting SARS-CoV-2 infection and replication in vitro . While its efficacy is debated, HCQ has been associated wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: adec2857-ae12-5afe-b7dd-3e9716640928
DOI: 10.1101/2021.06.25.449913

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Use of hiPSC-derived cardiomyocytes to rule out proarrhythmic effects of drugs: the case of hydroxychloroquine in COVID-19DOI 10.1101/2021.06.25.449913Read

Comprehensive preclinical evaluation of how cardiac safety profiles of potential COVID-19 drugs are modified by disease associated factors.Semantic proximity Read

Moving beyond the comprehensive in vitro proarrhythmia assay: Use of human-induced pluripotent stem cell-derived cardiomyocytes to assess contractile effects associated with drug-induced structural cardiotoxicity.Semantic proximity Read

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes.Semantic proximity Read

Prime-edited isogenic hiPSC-derived cardiomyocyte model of short QT syndrome type 3 reveals electrophysiological phenotypes and differential drug responses.Semantic proximity Read

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.Semantic proximity Read

In vitro to in vivo extrapolation from 3D hiPSC-derived cardiac microtissues and physiologically based pharmacokinetic modeling to inform next-generation arrhythmia risk assessmentSemantic proximity Read

Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cellsSemantic proximity Read

Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome.Semantic proximity Read

Effects of hydroxychloroquine on atrial electrophysiology in in silico wild-type and PITX2+/- atrial cardiomyocytesSemantic proximity Read

Use of hiPSC-derived cardiomyocytes to study LQTS-variant specific proarrhythmic effects of drugs.Semantic proximity Read

A machine learning platform for genotype-specific cardiotoxicity risk prediction using patient-derived iPSC-CMs.Semantic proximity Read

An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities.Semantic proximity Read