Article
Systematic evaluation of a predator stress model of depression in mice using a hierarchical 3D-motion learning framework.
Translational psychiatry - 25 May 2023
Tseng Yu-Ting, Zhao Binghao, Ding Hui, Liang Lisha, Schaefke Bernhard, Wang Liping
Abstract excerpt
Investigation of the neurobiology of depression in humans depends on animal models that attempt to mimic specific features of the human disorder. However, frequently-used paradigms based on social stress cannot be easily applied to female mice which has led to a large sex bias in preclinical studies of depression. Furthermore, most studies focus on one or only a few behavioral assessments, with time and practical...
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