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Article

Multimodal Behavioral Phenotyping Of Stress-Induced Depression-like States In Drosophila melanogaster.

Journal of visualized experiments : JoVE - 22 Jun 2026

Krama Tatjana, Popovs Sergejs, Garajeva Samira J, Krams Ronalds, Adams Colton B, Rantala Markus J, Trakimas Giedrius, Jõers Priit, de Bivort Benjamin L, Krams Indrikis

Abstract excerpt

Metabolic, neurodegenerative, and stress-related disorders are frequently accompanied by altered locomotion, impaired decision-making, and reduced behavioral flexibility. However, accessible multimodal behavioral frameworks for quantifying these phenotypes in Drosophila melanogaster remain limited. Here, a protocol integrating forced swim exposure, Y-maze turning behavior and handedness, phototaxis, and activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42406687
DOI: 10.3791/71280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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