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Article

Dolutegravir-associated resistance mutations after first-line treatment failure in Brazil.

BMC infectious diseases - 24 May 2023

Diaz Ricardo Sobhie, Hunter James R, Camargo Michelle, Dias Danilo, Galinskas Juliana, Nassar Isabela, de Lima Isaac Barbosa, Caldeira Debora Bellini, Sucupira Maria Cecilia, Schechter Mauro

Abstract excerpt

BACKGROUND: Since January 2017, the recommended first-line antiretroviral regimen in Brazil is the fixed-dose combination of tenofovir plus lamivudine with dolutegravir (TL + D). According to the literature, integrase resistance-associated mutations (INRAMs) are rarely found upon virologic failure to first-line dolutegravir plus two nucleoside reverse transcriptase inhibitors. We evaluated the HIV antiretroviral...

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Source

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Identifiers

PMID: 37226112
DOI: 10.1186/s12879-023-08288-8
PMCID: PMC10210384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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